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medication affect some people differently than others , and a new study could help scientist understand why , possibly leading to the more - efficient design and production of pharmaceutic .
sure enzyme that break down drug in the liver carry out their chemic reactions much more efficiently than apothecary have been able to do in testing ground . The new finding give science a good idea of how the enzymes can do this : They go through a phase that scientists had suspect but had never examine before .
A family of enzymes known as P450s is found in many places in nature , and thehuman liverhas five or six character that are responsible for metabolizing about 75 pct of drug . ( enzyme are proteins that help cannonball along up chemical substance reactions . )
Researchers had hypothesized that , as P450 enzymes breach downpharmaceuticals , the enzyme pass through a very abbreviated , unstable state , dubbed " Compound I " by scientists . But the state is so fleeting no one had ever regard it .
The new sketch enchant a snapshot of P450s in this state by freezing them at just the right second .
Now that scientists can freeze Compound I , they can more thoroughly examine how the enzymes interact withdrugs . Doing so may aid them larn why some people experiencebad reaction to drugs , or why some people metabolize drug or other compounds quicker than others do , the investigator tell .
For instance , P450s help break down Tylenol , opiates and caffeine , and people have variations of P450s that may affect the way the enzymes interact with these inwardness , the research worker tell .
Also , P450s channel out some peculiarly knavish chemistry , and understand the processes may serve scientists mimic them , which in twist could help them work up drugs . It also could be helpful for industries that expend similar reactions to make products , such as nylon , say study research worker Michael Green , a prof of alchemy at Penn State University .
Green and his colleagues first grew P450s inside the bacteria E. coli . Then they cool down the enzyme to almost minus 328 degrees Fahrenheit ( minus 200 degree Anders Celsius ) , which froze the response in a thousandth of a second . The researchers were then able to analyze the enzyme and see it in the Compound I tell .
The discipline will be print Nov. 12 in the journal Science .
This article was provided byMyHealthNewsDaily , a sister internet site to LiveScience .
